Skip to content Now you can get on with your day after routine dental procedures, thanks to a new product that reverses the effects of local anesthesia.
Tachycardia, bradycardia, and cardiac arrhythmia may occur with the use of phentolamine or other alpha-adrenergic blocking agents. Although such effects are uncommon with OraVerse (phentolamine mesylate), clinicians should be alert to the signs and symptoms of these events, particularly in patients with a history of cardiovascular disease. Following parenteral use of phentolamine at doses between 5 to 15 times higher than the recommended dose of OraVerse, myocardial infarction, and cerebrovascular spasm and occlusion have been reported, usually in association with marked hypotensive episodes producing shock-like states.
Median time to recovery of normal sensation was reduced by 85 minutes (55%) in the mandible and by 83 minutes (62%) in the maxilla compared to control. Median time to recovery of normal function was reduced by 60 minutes (50%) in the mandible and by 45 minutes (43%) in the maxilla.
